Publications by authors named "L Aguilar-Lopez"
Article Synopsis
- The most common genetic issue in chronic lymphocytic leukemia (CLL) patients is a deletion at chromosome band 13q14, which can vary in size and impact prognosis, particularly if it includes the larger associated gene deletions.
- A specific CLL case showed a chromosomal translocation (t(12;13)) along with a deletion affecting both crucial genes in the 13q14 region, indicating a level of genomic instability.
- Genomic instability in this patient was evidenced by various cytogenetic abnormalities, including chromosomal breaks and telomere shortening, suggesting a complex interaction between the deletions and the stability of the genome.
F8 inversions of introns 22 and 1 confer a moderate risk of inhibitors in Mexican patients with severe hemophilia A. Concordance analysis and literature review.
Hilda Luna-Záizar José Ángel González-Alcázar Natalia Evangelista-Castro Lilia Beatriz Aguilar-López Sandra Luz Ruiz-Quezada
Blood Cells Mol Dis
July 2018
Intron-22 (Inv22) and intron-1 (Inv1) inversions account for approximately one half of all severe cases of hemophilia A (SHA) worldwide. Inhibitor development against exogenous factor VIII (FVIII) represents a major complication in HA. The causative F8 mutation is considered the most decisive factor conditioning inhibitor development.
View Article and Find Full Text PDFB-cell Acute Lymphoblastic Leukemia With t(9;22)(q34;q11) Translocation and Clonal Divergence Through ider(22) Chromosome and t(13;17)(q14;q25) Translocation.
Juan Pablo Meza-Espinoza Enrique Jhonatan Romo Martínez Lilia Aguilar López Verónica Judith Picos Cárdenas María Teresa Magaña Torres
Ann Lab Med
March 2016
Introducction: Acute lymphoblastic leukemia (ALL) is a clonal disease characterized by a proliferation of immature cells. In immunophenotypic, cytogenetic and molecular studies, it is a heterogeneous disease with diverse manifestations and prognoses. The treatment is complex and is associated with complications during its course.
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