Prospective, Randomized Clinical Trial of Povidone-Iodine 1.25% Solution Versus Topical Antibiotics for Treatment of Bacterial Keratitis.

Purpose: To compare povidone-iodine 1.25% ophthalmic solution with topical antibiotics for treatment of bacterial keratitis in areas of the world where use of effective topical antibiotics may not be an option.

Study Design: Randomized, controlled, investigator-masked clinical trial.

A double application approach to ophthalmia neonatorum prophylaxis.

Aims: To investigate if a second drop of 2.5% povidone-iodine ophthalmic solution placed within the first postnatal day would achieve better prophylaxis against ophthalmia neonatorum than a single drop applied at birth.

Methods: A masked, prospective, controlled trial was conducted over a 2 year period in a Kenyan hospital.

A controlled trial of povidone-iodine to treat infectious conjunctivitis in children.

Purpose: To report the efficacy of povidone-iodine as a treatment for conjunctivitis in pediatric patients.

Design: Double-masked, controlled, prospective clinical trial.

Methods: In an ophthalmology clinic in a general hospital in Manila, Philippines, 459 children (mean [SD] age 6.

Ocular applications of povidone-iodine.

Ocular infections can have devastating consequences and may lead to blindness. Povidone-iodine (PVP-I) has many potential advantages over the currently used drugs, including a broader antibacterial spectrum, it turns the surface of the eye brown for a few minutes, bacterial resistance has not been seen and it is cheaper than other agents. PVP-I has made a significant contribution to pre- and postoperative ocular surgical prophylaxis, ophthalmia neonatorum prophylaxis and treatment of bacterial conjunctivitis.