Publications by authors named "L A van Kleef"
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming increasingly prevalent in the general population. This study aimed at describing the cardiometabolic burden of the MASLD population and to identify patients at the highest risk of all-cause mortality and liver fibrosis.
Methods: We analysed individuals with MASLD enrolled in the National Health and Nutrition Survey (NHANES) III study (N = 3,628) and in the NHANES 2017-2020 study (n = 2,618).
Background: Obesity can result in persistent metabolic changes despite weight loss, which may affect liver health. We aimed to investigate associations between young adulthood obesity and metabolic dysfunction-associated steatotic liver disease (MASLD), at-risk steatohepatitis and increased liver stiffness measurement (LSM) in a general population setting.
Methods: We studied NHANES 2017-2020 community-dwelling participants aged > 40 years with BMI ≥ 18.
Article Synopsis
- There is a growing need for noninvasive tests to help primary care physicians identify patients at high risk for liver disease, leading to the development of the MAF-5 score.
- The MAF-5 score was created from a study of 21,797 individuals with metabolic dysfunction and is based on factors such as waist circumference, body mass index, diabetes, and specific blood tests.
- MAF-5 demonstrated higher diagnostic accuracy compared to existing scores, particularly in predicting fibrosis and assessing liver stiffness, making it a promising tool for clinical use.