[Plasmapheresis in the combined treatment of rheumatoid arthritis, complicated with anemia and blood coagulation disorders].

Time course of changes in hemostasis were investigated in 68 rheumatoid arthritis (RA) patients. DIC syndrome and anemia were recorded in 23 and 20 patients, respectively. Three RA sufferers were free of anemia.

[Anemic syndrome in chronic hepatitis and liver cirrhosis].

Regularities in the development of anemia in patients with chronic hepatitis or hepato-cirrhosis were studied with regard to the pattern and stage of the affection of the liver. The impact of inefficient erythropoiesis on anemia development in patients with chronic diffuse diseases of the liver was demonstrated. Reasons of the red cells imperfection that caused their rapid hemolysis were indicated.

[Therapeutic plasmapheresis in chronic diffuse diseases of the liver].

The results of the clinico-laboratory investigations conducted in time course have evidenced a high therapeutic effectiveness of plasmapheresis in the complex treatment of patients with chronic active hepatitis and biliary cirrhosis of the liver. Plasmapheresis use has been validated and indicated in patients with a manifest biliary component, a high degree of the process activity and ineffectiveness or low effectiveness of the previous treatment.

[Relation between circulating immune complexes and serum ferritin in hemosiderosis of different etiologies].

Parameters of iron metabolism and humoral immunity were studied in patients with chronic diffuse diseases of the liver (cirrhosis, chronic hepatitis), beta-thalassemia major, dyserythropoiesis, hereditary hemochromatosis. High ferritin content has been recorded in the plasma of these patients, that leads to the formation of antibodies to this protein followed by the production of circulating immune complexes inducing metabolic disorders that aggravate the pathologic process. Plasmapheresis and deferoxamine therapy result in a decrease of ferritin and circulating immune complex content in the plasma, that produces a favourable effect on the patients' condition.