Eight monoterpene indole alkaloids (-), including one new picraline-type alkaloid, 2-hydroxyakuammiline () and seven known compounds: akuammigine (), akuammine (), akuammidine (), akuammiline (), akuammiline N-oxide (), akuammiline (), rhazimol (), and alstonine () were isolated from the seeds of . Structure elucidation was done by analysis of their MS and NMR spectroscopic data. The antiplasmodial effects of compounds - were moderate.
View Article and Find Full Text PDFObjective: Aging-related changes and caregiver burden may increase the risk for sleep disturbances among older caregivers, yet few studies have examined the prevalence of insomnia and daytime sleepiness in this group. We examined the relationship of caregiver status with insomnia and daytime sleepiness among persons of advanced age (>75 years of age).
Design: Cross-sectional.
Background: The BRIGhTMIND study was a double-blind RCT comparing repetitive transcranial magnetic stimulation at a standard simulation site (the "F3" location given by the International 10-20 system, F3-rTMS) versus connectivity-guided intermittent theta burst stimulation (cgiTBS) for treatment-resistant depression. This present study reports the acceptability, safety, and tolerability of F3-rTMS versus cgiTBS.
Methods: The present study used quantitative and qualitative methods.
Background: Sleep disturbances are common and distressing for people with dementia and their families. Non-pharmacological interventions should be first-line management, avoiding harmful pharmacological side-effects, but there is none with known effectiveness. We aimed to establish whether DREAMS START, a multicomponent intervention, reduced sleep disturbance in people with dementia living at home compared with usual care.
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