Publications by authors named "L A Waite"
Background: Despite a potentially greater burden of dementia, racial and ethnic minority populations around the world may be more likely to be excluded from research examining risk factors for incident dementia. We aimed to systematically investigate and quantify racial and ethnic minority representation in dementia risk factor research.
Methods: We performed a two-stage systematic search of databases-MEDLINE (Ovid SP), Embase (Ovid SP) and Scopus-from inception to March 2021 to identify population-based cohort studies looking at risk factors for dementia incidence.
Healthy cognition requires inhibitory modulation of associative learning; conversely, impaired inhibitory discrimination is implicated in behavioral disorders. The medial prefrontal cortex (mPFC) and its dopamine innervation are key to understanding inhibition and impulsivity. We therefore examined the role of prelimbic and infralimbic cortices in within-subjects appetitive feature-negative learning using microinfusions of (a) the gamma-aminobutyric acid-A receptor agonist muscimol (0.
View Article and Find Full Text PDFWe performed a systematic review and meta-analysis of hypertension in people living with human immunodeficiency virus (HIV) in sub-Saharan Africa (SSA). We searched the PubMed, Google Scholar, African Index Medicus, and Embase databases to identify studies published from January 1, 2010, to December 31, 2021. We used a random-effects model to estimate the pooled prevalence of hypertension and mean SBP/DBP level on a sex-specific basis.
View Article and Find Full Text PDFArticle Synopsis
- - Established drug therapies for Alzheimer’s, like cholinesterase inhibitors and memantine, offer limited benefits and do not change the disease progression; meanwhile, biomarker measures (amyloid, tau, neurodegeneration) are essential for clinical trial effectiveness and patient selection.
- - Two monoclonal antibodies, aducanumab and lecanemab, have been approved in the U.S. for targeting amyloid-beta, showing the ability to remove amyloid from the brain in early Alzheimer’s patients, though cognitive improvements are statistically significant but not clinically meaningful.
- - The approach of solely targeting amyloid may not be enough, suggesting future therapies need to address multiple pathways, especially since dementia mainly affects the elderly and complex
Article Synopsis
- - This research examined how heat affects the upper body of firefighters and their protective gear after intense heat exposure, confirming a hypothesis that the head and helmet would be the hottest areas.
- - Twenty participants exercised for 21 minutes in a humid and hot environment while wearing firefighter gear, with various body parts and PPE analyzed for temperature.
- - Results showed the head, chest, and upper back were the hottest post-exercise, while the abdomen was the coolest, highlighting the need for better cooling strategies for firefighters.