Publications by authors named "L A Tedesco"
Purpose: The purpose of this study was to conduct a systematic review evaluating the reported complications and outcomes of bone-anchored prostheses in digit and partial hand amputees.
Methods: A literature review of primary research articles on osseointegration and bone-anchored prostheses for digit and partial amputees was performed. The Medline, Embase, Scopus, and Cochrane Library databases were queried.
Bone Graft and Fixation Options in the Surgical Management of Scaphoid Nonunion.
J Am Acad Orthop Surg
October 2024
Article Synopsis
- Scaphoid nonunions are challenging for hand surgeons due to the scaphoid's poor blood supply, leading to the need for internal fixation and bone grafts for treatment.
- Various bone graft options exist depending on the patient's condition, blood supply, and any deformities, including nonvascularized autologous grafts from different body areas and vascularized grafts for blood supply concerns.
- The review emphasizes the importance of using bone grafts to enhance internal fixation, promote healing, and restore alignment in cases of scaphoid nonunions.
Rotator cuff repair surgeries fail frequently, with 20 to 94% of the 600,000 repairs performed annually in the United States resulting in retearing of the rotator cuff. The most common cause of failure is sutures tearing through tendons at grasping points. To address this issue, we drew inspiration from the specialized teeth of snakes of the Pythonoidea superfamily, which grasp soft tissues without tearing.
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- Mucopolysaccharidosis type I Hurler (MPSIH) causes severe skeletal issues that aren't fully improved by traditional stem cell transplants (HSCT), but autologous gene therapy (HSPC-GT) shows promise for better metabolic outcomes.
- In a clinical trial with eight young patients (average age 1.9 years), those who underwent HSPC-GT were evaluated over four years for various growth and skeletal measures, showing significant improvements compared to those treated with HSCT.
- After nearly four years, HSPC-GT patients demonstrated better growth, joint mobility, and reduced signs of hip dysplasia, indicating early positive impacts on skeletal health, but more long-term data is needed for con