The management of acute myocardial infarction in the Russian Federation: protocol for a study of patient pathways.

Background: Death rates from cardiovascular disease in Russia are among the highest in the world. In recent years, the Russian government has invested substantially in the healthcare system, with a particular focus on improving access to advanced technology, especially for acute myocardial infarction (AMI). This protocol describes a study to understand the management of AMI in different Russian regions, investigating the role of patient, clinical, and health system characteristics.

[Protein-synthesizing function of neutrophils and lipid-releasing ability of leukocytes in patients with atherosclerosis].

Concentrations of defensins-alpha, lipoprotein(α), C-reactive protein, proBNP, VII- coagulation factor and von Wilebrandt factor were measured in supernatants of 3-day leukocyte cultures enriched with neutrophils in order to estimate their synthesis in patients with stable angina and atherosclerosis of lower extremities. In addition, in vitro tumor necrosis factor-alpha test was performed. Simultaneously, concentrations of serum interleukine-6, -8, defensins-alpha, C-reactive protein, proBNP, VII-coagulation factor were determined.

[Serum markers of inflammation and lipid-releasing ability of leukocytes in patients with arterial hypertension and angina of effort].

Detection of cardiovascular risk factors remains a challenging problem. The inflammatory mechanisms behind atherosclerosis imply active involvement of neutrophils and realization of lipid-releasing ability of leukocytes (LRAL) mediated through the synthesis of proatherogenic proteins with the formation of protein-lipid complexes accumulated around atherosclerotic lesions. Studies of compromised protein-synthesizing function and mechanisms regulating LRAL are currently underway.