A case report of polymyalgia rheumatica.

The presented case report concerns a 62-year-old male patient who was admitted to the rheumatology department with a fever, shoulder and hip joint pain, significant limitation of movement in these joints and general weakness. Laboratory test revealed increase of inflammatory parameters, as ESR and C-reactive protein, rheumatoid factor and ACPA antibodies were absent. In the course of diagnostics, infections and cancer were excluded.

[The effect of amiridin and tacrine on the potassium currents in a nerve fiber].

The experiments on isolated nerve fibers from the frog Rana ridibunda have demonstrated that aminoacridine tacrin and aminocholine amiridine given in a concentration of 1 microM induced a 3-4 mV increase in the resting potential of the intact Ranvier nodal membrane depolarized by several millivolts by external source current, accompanied by a rise in the amplitude and curvature of action potential. With the voltage clamp, the two agents shifted a steady state potassium conductivity vs. the voltage curve measured in the vicinity of the resting potential in isotonic KCl solution.

[Effects of prospidin on the development of pulmonary metastases of Lewis tumors in rats in regard to changes in the level of extracellular calcium].

The effect of prospidin on Lewis lung carcinoma spreading under hyper- and hypocalcemia was studied. At early stages, increased extracellular calcium level was associated with inhibition of tumor dissemination to the lungs; however, later, colony growth was stimulated. Extracellular calcium level was shown to modulate the antitumor and antimetastatic effect of prospidin.

[Separation of undamaged single nerve fibers by using an ultrasonic microscalpel].

A routine procedure for dissection of single nerve fibres with sharpened sewing needles is rather tiresome and occasionally traumatic because of poor efficiency in cutting interfibrous connective tissue and sticking out patches of it to preparative needles. The described method using microscalpel oscillating with ultrasonic frequency is free from these shortcomings. Voltage clamp tests proved an innocuous character of this method for excitable nodal membrane.

The effect of yohimbine on sodium and gating currents in frog Ranvier node membrane.

The indolalkylamine alkaloid yohimbine induced two phenomenologically-different types of sodium current (INa) inhibition in the voltage-clamped frog node of Ranvier, a tonic and a phasic ('use-dependent') block. The latter developed during a repetitive membrane stimulation with short (5 ms) depolarizing pulses at frequencies at 1 to 10 Hz. Unlike repetitive pulsing, a single-long lasting (1 s) depolarizing step did not produce a phasic block.