Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2).

Objectives: To investigate the efficacy and safety of otilimab, an antigranulocyte-macrophage colony-stimulating factor antibody, in patients with active rheumatoid arthritis.

Methods: Two phase 3, double-blind randomised controlled trials including patients with inadequate responses to methotrexate (contRAst 1) or conventional synthetic/biologic disease-modifying antirheumatic drugs (cs/bDMARDs; contRAst 2). Patients received background csDMARDs.

Anti-GM-CSF otilimab versus sarilumab or placebo in patients with rheumatoid arthritis and inadequate response to targeted therapies: a phase III randomised trial (contRAst 3).

Objectives: To investigate the efficacy and safety of otilimab, an anti-granulocyte-macrophage colony-stimulating factor antibody, in patients with active rheumatoid arthritis and an inadequate response to conventional synthetic (cs) and biologic disease-modifying antirheumatic drugs (DMARDs) and/or Janus kinase inhibitors.

Methods: ContRAst 3 was a 24-week, phase III, multicentre, randomised controlled trial. Patients received subcutaneous otilimab (90/150 mg once weekly), subcutaneous sarilumab (200 mg every 2 weeks) or placebo for 12 weeks, in addition to csDMARDs.

Wide-Field-of-View Multispectral Camera Design for Continuous Turfgrass Monitoring.

Sustainably using resources, while reducing the use of chemicals, is of major importance in agriculture, including turfgrass monitoring. Today, crop monitoring often uses camera-based drone sensing, offering an accurate evaluation but typically requiring a technical operator. To enable autonomous and continuous monitoring, we propose a novel five-channel multispectral camera design suitable for integrating it inside lighting fixtures and enabling the sensing of a multitude of vegetation indices by covering visible, near-infrared and thermal wavelength bands.

Freeform Wide Field-of-View Spaceborne Imaging Telescope: From Design to Demonstrator.

Wide field-of-view imaging optics offer a huge potential for space-based Earth observation enabling the capture of global data. Reflective imaging telescopes are often favored, as they do not show chromatic aberrations and are less susceptible to radiation darkening than their refractive counterparts. However, the main drawback of reflective telescopes is that they are limited with respect to field-of-view while featuring large dimensions.

A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR).

Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) and dysregulated myeloid cell responses are implicated in the pathophysiology and severity of COVID-19.

Methods: In this randomised, sequential, multicentre, placebo-controlled, double-blind study, adults aged 18-79 years (Part 1) or ≥70 years (Part 2) with severe COVID-19, respiratory failure and systemic inflammation (elevated C-reactive protein/ferritin) received a single intravenous infusion of otilimab 90 mg (human anti-GM-CSF monoclonal antibody) plus standard care (NCT04376684). The primary outcome was the proportion of patients alive and free of respiratory failure at Day 28.