Publications by authors named "L A Saint-Louis"
Introduction: We examined whether hypertension (HTN) was associated with Alzheimer's disease-related biomarkers in cerebrospinal fluid (CSF) and how changes in blood pressure (BP) related to changes in CSF biomarkers over time.
Methods: A longitudinal observation of cognitively healthy normotensive subjects (n = 134, BP < 140/90, with no antihypertensive medication), controlled HTN (n = 36, BP < 140/90, taking antihypertensive medication), and 35 subjects with uncontrolled HTN (BP ≥ 140/90). The follow-up range was 0.
Article Synopsis
- - The study investigates whether the nasal mucosa serves as a drainage site for cerebrospinal fluid (CSF) in humans, particularly in the context of Alzheimer's disease (AD).
- - Using dynamic PET imaging with a specific radiotracer, researchers found a correlation between the drainage times of fluid in the brain and nasal pathways, particularly in subjects with amyloid presence.
- - Results suggest that the nasal pathway is linked to brain amyloid status and may contribute to understanding protein clearance in neurodegenerative diseases; further research is encouraged.
Cerebrospinal fluid (CSF), predominantly produced in the ventricles and circulating throughout the brain and spinal cord, is a key protective mechanism of the central nervous system (CNS). Physical cushioning, nutrient delivery, metabolic waste, including protein clearance, are key functions of the CSF in humans. CSF volume and flow dynamics regulate intracranial pressure and are fundamental to diagnosing disorders including normal pressure hydrocephalus, intracranial hypotension, CSF leaks, and possibly Alzheimer's disease (AD).
View Article and Find Full Text PDFThe human brain functions at the center of a network of systems aimed at providing a structural and immunological layer of protection. The cerebrospinal fluid (CSF) maintains a physiological homeostasis that is of paramount importance to proper neurological activity. CSF is largely produced in the choroid plexus where it is continuous with the brain extracellular fluid and circulates through the ventricles.
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