Publications by authors named "L A S Mol"
Background: Chest tube insertions (CTI) have a high complication rate, warranting a dedicated Simulation-Based Mastery Learning (SBML) curriculum to acquire technical skills. This randomized controlled trial compares residents' skills in CTI after completing a SBML curriculum with those enrolled in a traditional residency program.
Methods: Junior residents were baseline tested on cognitive and technical skills (Thiel bodies) before randomization into an intervention and control group.
Article Synopsis
- CDK4/6 inhibitors combined with endocrine therapy improve outcomes for patients with hormone-receptor positive, HER2-negative advanced breast cancer, but evidence comparing first-line and second-line use is limited.
- The phase 3 SONIA trial involved 1,050 patients and showed no significant overall benefit for using CDK4/6 inhibitors first-line compared to second-line (31.0 vs. 26.8 months median progression-free survival).
- Although first-line treatment led to longer duration of CDK4/6 therapy and more severe side effects, the quality of life was similar for both treatment timing, questioning the necessity for first-line CDK4/6 inhibitor usage in all cases.
Article Synopsis
- The CAIRO4 study aimed to determine if upfront primary tumor resection (PTR) combined with systemic therapy improves overall survival in patients with synchronous unresectable metastatic colorectal cancer (mCRC).
- Conducted in The Netherlands and Denmark, the trial involved 206 patients who were randomly assigned to receive either PTR plus systemic therapy or systemic therapy alone, with the primary endpoint being overall survival.
- Results showed that median overall survival was slightly higher for the upfront PTR group (20.1 months) compared to the no PTR group (18.3 months), but the difference was not statistically significant (P = 0.32), indicating no clear benefit from adding PTR to treatment.
The immovable nature of built heritage means that it is particularly vulnerable during times of armed conflict. Although impacts from small arms and shrapnel leave relatively inconspicuous impact scars, they elevate the risk of future stone deterioration. This study investigates the subsurface damage caused by bullet impacts, which is not apparent from surface inspection, in order to better understand the geometry and mechanics of this form of conflict damage to heritage.
View Article and Find Full Text PDFKrüppel-associated box (KRAB) zinc finger proteins (KZNFs) recognize and repress transposable elements (TEs); TEs are DNA elements that are capable of replicating themselves throughout our genomes with potentially harmful consequences. However, genes from this family of transcription factors have a much wider potential for genomic regulation. KZNFs have become integrated into gene-regulatory networks through the control of TEs that function as enhancers and gene promoters; some KZNFs also bind directly to gene promoters, suggesting an additional, more direct layer of KZNF co-option into gene-regulatory networks.
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