Publications by authors named "L A Ruttan"
Article Synopsis
- The study aims to identify distinct groups based on symptom intensity (fatigue, anxiety, depression, etc.) in patients with Systemic Lupus Erythematosus (SLE) and observe changes over a year.
- Results showed three symptom intensity clusters: mild, moderate, and severe, with varying stability; 49% of patients remained in their initial cluster after one year, particularly those in the mild cluster (77%).
- The findings suggest that patients in moderate symptom clusters could benefit from interventions to better manage their symptoms and potentially prevent deterioration to severe levels.
Post-acute sequelae of SARS-COV-2 (PASC) is growing in prevalence, and involves symptoms originating from the central neurological, cardiovascular, respiratory, gastrointestinal, autonomic nervous, or immune systems. There are non-specific symptoms such as fatigue, headaches, and brain fog, which cannot be ascribed to a single system. PASC places a notable strain on our healthcare system, which is already laden with a large number of acute-COVID-19 patients.
View Article and Find Full Text PDFObjective: Cognitive impairment (CI) is one of the most common manifestations of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). Despite its frequency, we have a limited understanding of the underlying immune mechanisms, resulting in a lack of pathways to target. This study aims to bridge this gap by investigating differences in serum analyte levels in SLE patients based on their cognitive performance, independently from the attribution to SLE, and exploring the potential for various serum analytes to differentiate between SLE patients with and without CI.
View Article and Find Full Text PDFPurpose: There is limited research regarding the characteristics of those from the general population who seek care following acute concussion.
Methods: To address this gap, a large cohort of 473 adults diagnosed with an acute concussion (female participants = 287; male participants = 186) was followed using objective measures prospectively over 16 weeks beginning at a mean of 5.1 days post-injury.
Background: More than a quarter of adults with concussion endure prolonged symptoms of >3 months. We developed the Concussion Education Self-Management program to help people manage persisting symptoms. Here, we assess feasibility, preliminary efficacy, and correlates of response.
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