Publications by authors named "L A Rokeach"
Article Synopsis
- Cell fate is influenced by the balance of apoptosis (cell death) and autophagy (cell survival), with autophagy helping cells recycle components during stress like nitrogen starvation or aging.
- Calnexin (Cnx1p), a crucial protein in the endoplasmic reticulum, plays a key role in regulating apoptosis and is processed into two forms during stationary growth.
- The cleavage of Cnx1p, regulated by autophagy and specific proteases, is essential for cell survival under stress, as its absence leads to increased cell death and various cellular defects in yeast, suggesting Cnx1p is a critical link between pro-death and pro-survival processes.
We present results showing that glucose signaling has proaging effects in the yeast Schizosaccharomyces pombe. Deletion of the receptor that senses extracellular glucose (Git3) increases the life span of S. pombe, while constitutive activation of the Galpha subunit acting downstream of this receptor (Gpa2) shortens its life span.
View Article and Find Full Text PDFFission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes.
J Gerontol A Biol Sci Med Sci
January 2010
Article Synopsis
- Simple organisms like yeasts and worms have significantly advanced our understanding of aging by revealing molecular mechanisms and discovering longevity genes.
- Studies on the yeast Saccharomyces cerevisiae have shown that these longevity genes are often conserved in more complex organisms.
- Research is now expanding to other yeast models, such as Schizosaccharomyces pombe, focusing on the relationship between cell division, nutrient signaling, and aging mechanisms.
The molecular chaperone Hsp104 is a crucial factor in the acquisition of thermotolerance in yeast. Under stress conditions, the disaggregase activity of Hsp104 facilitates the reactivation of misfolded proteins. Hsp104 is also involved in the propagation of fungal prions.
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