Dileucine ingestion, but not leucine, increases lower body strength and performance following resistance training: A double-blind, randomized, placebo-controlled trial.

Background: The essential amino acid leucine (LEU) plays a crucial role in promoting resistance-training adaptations. Dileucine (DILEU), a LEU-LEU dipeptide, increases MPS rates, however its impact on resistance training outcomes remains unexplored. This study assessed the effects of DILEU supplementation on resistance training adaptations.

Linking Newborns and Mothers to Enable the Study of Inter-generational Health Outcomes: Evidence from Nationwide Medicaid Data.

Linking mothers to their newborns in health records is crucial for understanding the impact of policies, programs, and medical treatments on inter-generational health outcomes. While previous studies have used shared identifiers like names or addresses for linkage, such data are often unavailable in Medicaid records due to privacy concerns. We present a scalable framework and linking algorithm using Medicaid MAX and TAF claims data-lacking direct identifiers-that connects mothers and infants while ensuring privacy protection.

Gender challenges within the UK Defence Medical Services: recruiting and retaining a diverse workforce.

While there are women represented in some notable positions within the UK Defence Medical Services (DMS), the challenges and barriers to successful female progression have not disappeared. The DMS needs highly talented, motivated doctors working to support operations, yet we struggle to recruit and retain female personnel. This is in clear contrast to the increased proportion of female personnel working within the civilian medical workforce.

Targeted Protein Localization by Covalent 14-3-3 Recruitment.

14-3-3 proteins have a unique ability to bind and sequester a multitude of diverse phosphorylated signaling proteins and transcription factors. Many previous studies have shown that interactions of 14-3-3 with specific phosphorylated substrate proteins can be enhanced through small-molecule natural products or fully synthetic molecular glue interactions. However, enhancing 14-3-3 interactions with both therapeutically intractable transcription factor substrates and potential neo-substrates to sequester and inhibit their function remains elusive.