Ageing Perception and Social Relationships Moderate the Associations Between Health Stressors and Life Satisfaction in the Very Old: Evidence from the ELSA Study.

This study investigated whether social relationships and aging perceptions moderate the roles of health stressors on life satisfaction among very old adults (80+ years,  = 4,220) in the English Longitudinal Study of Aging (ELSA). Data were analyzed in R Lavaan using structural equation modeling with latent interactions. Positive ageing perception and the quality of social relationships with children and relatives attenuated the influence of mobility limitations on life satisfaction.

Special Education Law and Services for Pediatricians.

Rates of developmental screening have increased, and understanding how to discuss delays with families is imperative. Knowledge of federal and state law regarding special education is needed. Families often need support to understand the complexity of early intervention and school district-based services.

No major differences in perinatal and maternal outcomes between uninterrupted embryo culture in time-lapse system and conventional embryo culture.

Study Question: Is embryo culture in a closed time-lapse system associated with any differences in perinatal and maternal outcomes in comparison to conventional culture and spontaneous conception?

Summary Answer: There were no significant differences between time-lapse and conventional embryo culture in preterm birth (PTB, <37 weeks), low birth weight (LBW, >2500 g) and hypertensive disorders of pregnancy for singleton deliveries, the primary outcomes of this study.

What Is Known Already: Evidence from prospective trials evaluating the safety of time-lapse incubation for clinical use show similar embryo development rates, implantation rates, and ongoing pregnancy and live birth rates when compared to conventional incubation. Few studies have investigated if uninterrupted culture can alter risks of adverse perinatal outcomes presently associated with IVF when compared to conventional culture and spontaneous conceptions.

Imaging and quantification of the tumor microenvironment of triple negative breast cancer using TPEF and scanning laser optical tomography.

Triple-negative breast cancer is an aggressive subtype of breast cancer that has a poor five-year survival rate. The tumor's extracellular matrix is a major compartment of its microenvironment and influences the proliferation, migration and the formation of metastases. The study of such dependencies requires methods to analyze the tumor matrix in its native form.

Talking and making meaning about parental mental health problems: The role of children's family caregivers.

When a parent is less able to meet their children's needs due to a severe and enduring mental health problem (MHP), other adult family members often help with childcare. We present a Grounded Theory of how children's family caregivers construct meaning about the parental MHP and communicate about it with children. Nineteen caregivers participated in qualitative interviews.