Publications by authors named "L A Newcomb"
Importance: Active surveillance is the preferred management strategy for patients with low- or favorable intermediate-risk prostate cancer (PCa); however, frequent health care visits can be costly and burdensome to patients. Identifying patients who may benefit from intensive vs passive surveillance could reduce these burdens.
Objective: To investigate associations between a polygenic risk score (PRS) and risk of upgrading and other prostate tumor features in patients receiving active surveillance.
Background: Implications of relabeling grade group (GG) 1 prostate cancer as non-cancer will depend on the recommended active surveillance (AS) strategy. Whether relabeling should prompt de-intensifying, PSA-based active monitoring approaches is unclear. We investigated outcomes of biopsy-based AS strategies vs PSA-based active monitoring for GG1 diagnoses under different patient adherence rates.
View Article and Find Full Text PDFBackground: We previously reported that increases in circulating sphingolipids are associated with elevated risk of biopsy Gleason grade group (GG) upgrading in men on Active Surveillance (AS) for prostate cancer. Here, we aimed to validate these findings and establish a blood-based sphingolipid biomarker panel for identifying men on AS who are at high-risk of biopsy GG upgrading.
Methods: Men diagnosed with low- or intermediate-risk prostate cancer in one of two AS cohorts (CANARY PASS and MDACC) were followed for GG upgrading after diagnostic and confirmatory biopsy.
Article Synopsis
- Microbiology educators are focusing on helping students grasp essential concepts in virology due to rising vaccine hesitancy and misinformation surrounding COVID-19.
- There is a shortage of virologists teaching undergraduates, often leading to limited coverage in microbiology courses, which can hinder meaningful discussions about viral issues.
- A team of educators, supported by the American Society for Virology, developed curriculum guidelines for teaching virology in undergraduate settings, including measurable learning objectives to aid educators in implementing these guidelines.
Article Synopsis
- The study aims to improve the histological grading system for prostate cancer to better predict metastatic potential by focusing on specific high-risk patterns known as 'unfavourable histology.'
- Two patient cohorts were analyzed, one with long-term follow-up and the other with confirmed metastatic disease, to assess the impact of unfavourable histology on outcomes like biochemical recurrence and death.
- The findings showed that unfavourable histology significantly predicts outcomes, with high sensitivity for predicting recurrence and metastasis, suggesting that incorporating this model could enhance current grading practices in prostate cancer.