Publications by authors named "L A Nasif"
Article Synopsis
- This study investigates the molecular changes in insulin-secreting β-cells in individuals at the pre-symptomatic stage of type 1 diabetes (T1D) to better understand how the disease progresses.
- * Researchers used a proteomics approach to analyze islet sections from organ donors with islet autoantibodies, comparing them to nondiabetic controls to identify potential markers of β-cell dysfunction.
- * The analysis revealed about 202 proteins with significant differences between high-risk autoantibody-positive cases and controls, highlighting changes related to immune response, glycolysis, and decreased levels of endoplasmic reticulum stress response and protein synthesis.
Background: Coarctation of the aorta (CoA) often leads to hypertension posttreatment. Evidence is lacking for the current >20 mm Hg peak-to-peak blood pressure (BP) gradient (BPGpp) guideline, which can cause aortic thickening, stiffening, and dysfunction. This study sought to find the BPGpp severity and duration that avoid persistent dysfunction in a preclinical model and test if predictors translate to hypertension status in patients with CoA.
View Article and Find Full Text PDFBackground: Coarctation of the aorta (CoA) often leads to hypertension (HTN) post-treatment. Evidence is lacking for the current >20 mmHg peak-to-peak blood pressure gradient (BPGpp) guideline, which can cause aortic thickening, stiffening and dysfunction. This study sought to find the BPGpp severity and duration that avoid persistent dysfunction in a preclinical model, and test if predictors translate to HTN status in CoA patients.
View Article and Find Full Text PDFPathological tau inclusions are neuropathologic hallmarks of many neurodegenerative diseases. We generated and characterized a transgenic mouse model expressing pathogenic human tau with S320F and P301S aggregating mutations (SPAM) at transgene levels below endogenous mouse tau protein levels. This mouse model develops a predictable temporal progression of tau pathology in the brain with biochemical and ultrastructural properties akin to authentic tau inclusions.
View Article and Find Full Text PDFBeginning in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a novel pathogen that causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 has infected more than 111 million people worldwide and caused over 2.47 million deaths.
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