Publications by authors named "L A N Mimura"
Article Synopsis
- Candidiasis can affect the central nervous system (CNS), with non-albicans strains also implicated in infections linked to multiple sclerosis (MS).
- In a study, different non-albicans strains were tested on mice to see how they influenced experimental autoimmune encephalomyelitis (EAE), a model for MS, revealing varying effects on disease severity and immune responses.
- While some strains worsened EAE symptoms through virulence factors and immune cell activation, others showed no impact, suggesting that not all non-albicans strains equally influence CNS disease progression.
Effect of Rapamycin on MOG-Reactive Immune Cells and Lipopolysaccharide-Activated Microglia: An Approach for Screening New Therapies for Multiple Sclerosis.
J Interferon Cytokine Res
April 2022
Rapamycin is an immunomodulatory drug that has been evaluated in preclinical and clinical trials as a disease-modifying therapy for multiple sclerosis (MS). In this study, we evaluated the effect of rapamycin on immune cells pivotally involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), which is an animal model to study MS. Splenocytes and central nervous system (CNS)-mononuclear cells obtained from EAE mice were stimulated with a myelin oligodendrocyte glycoprotein peptide, whereas the microglial BV-2 cell line was activated with LPS.
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- Multiple sclerosis (MS) is an autoimmune disease that is treatable but not curable, with various medications available to help manage symptoms and reduce relapses.
- Treatment responses vary among patients, and some may experience significant side effects, prompting research into alternative therapies like vitamin D.
- The review highlights the similarities between the underlying mechanisms of MS and experimental autoimmune encephalomyelitis, discussing vitamin D's potential benefits and the importance of administration methods and timing for patients with MS.
Environmental factors, including infections, are strongly associated with the pathogenesis of multiple sclerosis (MS), which is an autoimmune and demyelinating disease of the central nervous system (CNS). Although classically associated with bacterial and viral agents, fungal species have also been suspected to affect the course of the disease. is an opportunistic fungus that affects immunocompromised individuals and is also able to spread to vital organs.
View Article and Find Full Text PDFMultiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). MS and its animal model called experimental autoimmune encephalomyelitis (EAE) immunopathogenesis involve a plethora of immune cells whose activation releases a variety of proinflammatory mediators and free radicals. Vitamin D3 (VitD) is endowed with immunomodulatory and antioxidant properties that we demonstrated to control EAE development.
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