Responding to the times: Adapting an evaluation study during a dual pandemic.

This paper is a critical essay to discuss an original methodological design for an equity school evaluation in diverse-by-design schools. The evaluation was to gather a broad swathe of data necessary to provide detailed insights on diverse-by-design schools in diversity, equity, and inclusion (DEI) practices. We chronicle and critically explore the methodological pivots generated by the research team as we conducted this research against the backdrop of both the COVID-19 pandemic and US nationwide protests in response to the murder of George Floyd and countless other Black people at the hands of the police.

Aerosolized drug-loaded nanoparticles targeting migration inhibitory factors inhibit -induced inflammation and biofilm formation.

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine, which has been shown to promote disease severity in cystic fibrosis. : In this study, aerosolized drug-loaded nanoparticles containing SCD-19, an inhibitor of MIF's tautomerase enzymatic activity, were developed and characterized. The aerosolized nanoparticles had an optimal droplet size distribution for deep lung deposition, with a high degree of biocompatibility and significant cellular uptake.

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.

Background/introduction: Sarcoidosis is a multi-systemic disorder of unknown etiology, characterized by the presence of non-caseating granulomas in target organs. In 90% of cases, there is thoracic involvement. Fifty to seventy percent of pulmonary sarcoidosis patients will experience acute, self-limiting disease.

Macrophage migration inhibitory factor enhances biofilm formation, potentially contributing to cystic fibrosis pathogenesis.

Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator that we have previously shown to be associated with an aggressive clinical phenotype in cystic fibrosis. It possesses unique tautomerase enzymatic activity. However, to date, no human-derived substrate has been identified that has the capacity to interact with this cytokine's unique tautomerase activity.

Healthcare providers' perspectives on the acceptability and uptake of HPV vaccines in Zimbabwe.

Background: Human papillomavirus (HPV) vaccines are a critical strategy in the prevention of cervical cancer, especially in countries like Zimbabwe where cervical cancer screening rates are low. In Zimbabwe, cervical cancer is the leading cause of cancer-related deaths in women but the HPV vaccine is not yet widely available. This study examined healthcare providers': (1) perceptions of current hospital practices and issues in cervical cancer prevention and treatment in Zimbabwe; (2) knowledge of HPV and HPV vaccines; and (3) perspectives on introducing HPV vaccination programs in Zimbabwe, including potential facilitators and barriers to successful implementation.