Publications by authors named "L A Marzano"
Article Synopsis
- MS diagnosis is particularly difficult in rare populations like Brazil, where early treatment is crucial for reducing disability, but late diagnosis can worsen the disease's progression.
- A study in Belo Horizonte scrutinized 66 MS patients' medical records to measure the time from first symptoms to diagnosis and treatment, finding significant delays in some cases.
- Results showed earlier diagnosis leads to less disability; those diagnosed within two years experienced symptoms at a younger age and had better outcomes.
The sodium chloride cotransporter (NCC) is essential for electrolyte balance, blood pressure regulation, and pathophysiology of hypertension as it mediates the reabsorption of ultrafiltered sodium in the renal distal convoluted tubule. Given its pivotal role in the maintenance of extracellular fluid volume, the NCC is regulated by a complex network of cellular pathways, which eventually results in either its phosphorylation, enhancing sodium and chloride ion absorption from urines, or dephosphorylation and ubiquitination, which conversely decrease NCC activity. Several factors could influence NCC function, including genetic alterations, hormonal stimuli, and pharmacological treatments.
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- Hypertension resolution after adrenalectomy in patients with primary aldosteronism (PA) is complex, and predicting which patients will normalize their blood pressure is both crucial and debated.
- A thorough review of literature from 1954 to 2024 found predictors like gender, duration of hypertension, medication use, and BMI, but inconsistencies across studies led to mixed results.
- Despite some evidence supporting predictive models for hypertension resolution, significant gaps and controversies exist, indicating a need for more research to validate and enhance these models.
Exploring Hospital Overcrowding with an Explainable Time-to-Event Machine Learning Approach.
Stud Health Technol Inform
August 2024
Emergency department (ED) overcrowding is a complex problem that is intricately linked with the operations of other hospital departments. Leveraging ED real-world production data provides a unique opportunity to comprehend this multifaceted problem holistically. This paper introduces a novel approach to analyse healthcare production data, treating the length of stay of patients, and the follow up decision regarding discharge or admission to the hospital as a time-to-event analysis problem.
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