Coexpression of two mRNA isoforms of insulin-like growth factor-1 gene and mRNA of YB-1 gene in patients with multiple myeloma.

Coexpression of two mRNA isoforms for insulin-like growth factor-1 (IGF-1A and IGF-1B) and expression of YB-1 mRNA were analyzed in the bone marrow aspirates from 19 patients with multiple myeloma. It was shown that mRNA isoforms for IGF-1A and IGF-1B were mainly expressed in samples with hyperexpression of YB-1 mRNA, and, on the contrary, practically were not expressed (except sporadic cases) in samples with low level of YB-1 mRNA expression. Coexpression of mRNA isoforms for IGF-1A and IGF-1B were observed in 80% patients with multiple myeloma.

[Comparison of effectiveness of treatment for cervical carcinoma using different brachytherapy equipment].

The immediate and end results of combined radiotherapy for cervical carcinoma stages I-III conducted at the N.N. Blokhin Center's Clinic (1982-1996) were compared.

[Effect of dosage in the planning of intracavitary irradiation].

A comparison was carried out of different procedures of evaluation of the role of dosage in contact radiation effect. The assets and liabilities of the available methods of evaluation were studied with respect to the Ellis--time-dose-fractionation and linear-quadratic concepts. It was demonstrated that the sublethal damage repair model evolved by H.

[Current possibilities of surgical and combined treatment of patients with uterine cancer].

Surgical treatment alone was given to 88 patients with endometrial tumors while 182 patients underwent combined therapy. Three-year survival was 92.1%: 88.