Publications by authors named "L A Lukas"
Article Synopsis
- A systematic literature review was conducted to evaluate the effects of commonly used medications on neurological recovery after acute spinal cord injury (SCI), with studies sourced from major databases until March 2021.
- *Out of 394 studies analyzed, around 42% of animal experiments showed positive disease-modifying effects from drugs like methylprednisolone and melatonin, while morphine and ethanol were linked to negative outcomes.
- *The findings suggest a need for more human-centered research to explore the potential benefits of drugs like melatonin and atorvastatin for improving recovery after SCI, despite varying research methodologies across studies.
Article Synopsis
- The text discusses a collection of maize mutants created through transposon insertions, aimed at aiding functional genomics research.
- It outlines methodologies for both reverse genetics—where researchers identify and characterize mutations using existing genetic data and confirmation techniques—and forward genetics, which involves using advanced sequencing methods to find the genes responsible for observed traits.
- The overall goal is to establish connections between specific genetic mutations and their effects on observable characteristics in maize.
Spinal cord injury (SCI) is a rare condition with a heterogeneous presentation, making the prediction of recovery challenging. However, serological markers have been shown to be associated with severity and long-term recovery following SCI. Therefore, our investigation aimed to assess the feasibility of translating this association into a prediction of the lower extremity motor scores (LEMS) at chronic stage (52 weeks after initial injury) in patients with SCI using routine serological markers.
View Article and Find Full Text PDFBackground And Objectives: Neurological and functional recovery after traumatic spinal cord injury (SCI) is highly challenged by the level of the lesion and the high heterogeneity in severity (different degrees of in/complete SCI) and spinal cord syndromes (hemi-, ant-, central-, and posterior cord). So far outcome predictions in clinical trials are limited in targeting sum motor scores of the upper (UEMS) and lower limb (LEMS) while neglecting that the distribution of motor function is essential for functional outcomes. The development of data-driven prediction models of detailed segmental motor recovery for all spinal segments from the level of lesion towards the lowest motor segments will improve the design of rehabilitation programs and the sensitivity of clinical trials.
View Article and Find Full Text PDFArticle Synopsis
- * Using a water tank system, dosimetric parameters such as percentage depth dose (PDD), peak to valley dose ratios (PVDR), and output factors (OFs) were measured and compared with planning system calculations, showing notable changes in PDD across different energies.
- * Findings indicate significant variations in GRID fields based on energy, with two Truebeam linacs showing less than 2% difference in PVDRs, while a set of equations and reference tables for GRID therapy are proposed for