Publications by authors named "L A Luciano"
Article Synopsis
- The study evaluated the use of frontline TKI therapy in elderly patients (75 years or older) with chronic phase chronic myeloid leukemia (CP-CML) among a large cohort of 332 patients.
- Results showed that 85.8% of patients received imatinib (IM), while 14.2% were treated with second-generation TKIs (2G-TKI) like dasatinib and nilotinib, with a notable percentage starting on reduced doses.
- The findings indicated increased usage of IM after generic versions became available in Italy, but significant discontinuation rates due to resistance and toxicities were observed, highlighting the need for personalized treatment assessments and further studies on lower TKI doses.
Herein, we present a thorough examination of the impact of maternal nutrition on fetal and infant neurodevelopment, focusing on specific nutrients and their critical roles in perinatal and pediatric health. Through a comprehensive narrative review of the literature, this study highlights the importance of a balanced maternal diet rich in nutrients like eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), folic acid, iron, and iodine in shaping children's neurological functions. Key findings underscore the influence of maternal nutrition during pregnancy and the peri-gestational period on children's cognitive, motor, speech, and socio-emotional development.
View Article and Find Full Text PDFPonatinib may be effective in chronic myeloid leukemia (CML) patients after failure of first/second line therapies. Although its efficacy for minimum plasma concentrations (C) is >21.3 ng/mL (equal to 40 nM), ponatinib may cause adverse events (AE) that require dose optimization.
View Article and Find Full Text PDFArticle Synopsis
- - Patients with chronic myeloid leukemia (CML) treated with nilotinib or ponatinib have a risk of arterial occlusive events (AOEs), prompting recommendations for cardiovascular risk assessments before starting treatment.
- - A study of 455 CML patients showed that using the updated SCORE2/SCORE2-OP algorithm, which accounts for various cardiovascular risk factors, identified a greater percentage of patients at high risk compared to the older SCORE method.
- - Those classified as high to very high risk under SCORE2/SCORE2-OP experienced a significantly higher incidence of AOEs, emphasizing the algorithm's importance in guiding treatment decisions and enhancing patient care management.
Background: The authors assessed the clinical utility of patient-reported symptom monitoring in the setting of newly diagnosed chronic myeloid leukemia (CML). The primary objective was to evaluate adherence to therapy.
Methods: The authors conducted an international prospective study that included patients with newly diagnosed, chronic-phase CML.