Arginine-containing tripeptide Pro-Arg-Gly is involved in the regulation of the function of anticoagulation and insular systems under persistent hyperglycemia.

Intranasal administration of regulatory peptide PRG to rats against the background of persistent hyperglycemia improves blood antiplatelet and anticoagulant-fibrinolytic potential and normalizes blood sugar in comparison with the corresponding parameters in control animals that did not receive the peptide. The fibrinolytic and antiplatelet activities of blood plasma remained elevated 6 days after peptide withdrawal against the background of unchanged glucose administration.

[The reactivity of the anticoagulatory system in sympathectomized animals under stress conditions due to acoustic trauma].

In rats of kind of Kruschinskij-Molodkina the number of cells in the stellate ganglion was diminished to 0.5% of the norm after eliminating the sympathetic tonus by means of guanethidine. These animals died of cardiac thrombosis during stress situations.