[A chronic hyperimmunocomplex process and its interrelationship with free radical-generating systems].

On chronic hyperimmunocomplex process (CHIP) model in rats of Wistar line (Cochrane C., Koffen D., 1973) we determined cAMP and cGMP concentration, nitrogen oxide (NO), urine, urine acid,--in muscle and clearance organs, and also in plasma.

[The participation of neutrophilic mechanisms in the pathogenesis of chronic elevated blood immune complexes].

For reproduction of chronic hyperimmunocomplexemia model the classic Cochrane C. G., 1973 elaboration was used.

[Biochemical mechanisms of the effect of prostaglandin E2 on the effect of parenteral nitrogenous nutrition].

Activation of lipid peroxidation (LPP) processes in the hepatocytes of animals suffering from toxic hepatitis leads to disorders of membrane function and causes disorders of transports processes (activity of adenosine triphosphatase, active sodium transport) in them. Administration of prostaglandin E2 (PGE2) as a potent antioxidant simultaneously with casein hydrolysate to animals with experimental pathology intensifies the effect of the nitrous preparation and promotes normalization of the studied processes (LPP, adenosine triphosphatase activity, active sodium transport). Thus, through its action on LPP and the transport systems, PGE2 influences the effect of casein hydrolysate.

[The effect of prostaglandin E2 on transport processes in the hepatocytes during parenteral feeding against a background of protein starvation].

Experiments were conducted in 50 white rats (180-220 g bw). Activities of total, Mg2-dependent, Na+, K+ and Ca2(+)-ATPases and sodium transport in hepatocytes of the animals under normal conditions and in the presence of protein deficiency were studied in five test series. Protein deficiency was found to be attended by a significant rise in the activity of the enzymes studied, and by disorders in sodium transport in hepatocytes.

[Effect of prostaglandin E2 on enzyme activity during parenteral feeding].

It has been shown that prostaglandin E2 increases the activity of aspartate aminotransferase, alanine aminotransferase in the liver and striated muscle in parenteral feeding and increases the activity of aldolase in the liver but reduces it in the striated muscle. This demonstrates the enzymatic component in the mechanism of action of prostaglandin E2 on organ-tissue metabolism in parenteral feeding.