Characterizing patient factors, perioperative interventions, and outcomes associated with inpatients falls after total knee arthroplasty.

Introduction: Mechanical falls represent a potential adverse event after total knee arthroplasty (TKA) and may introduce further injury and delay postoperative recovery. This study aimed to identify patient characteristics associated with inpatient falls, to determine the impact of inpatient falls on surgical outcomes following TKA, and to describe the relationship between tourniquet and/or adductor canal block (ACB) use and fall rates.

Methods: Patients undergoing primary, elective TKA at a single institution between 2018 and 2022 were retrospectively analyzed.

The Effectiveness of a Senokot Cocktail for Postoperative Constipation.

A senior staff registered nurse on an orthopaedic inpatient rehabilitation unit in an urban orthopaedic hospital utilized a "cocktail" of warm prune juice, lemon juice, and Senokot liquid for patients who presented to the rehabilitation unit after orthopaedic surgery without having had an initial postoperative bowel movement (BM). A pilot study (n = 30) using a quasi-experimental design was conducted to evaluate the effect of the cocktail versus liquid Senokot alone on the first postoperative BM. Several measurement tools were used, including the Bristol Stool Scale, visual analog scales to determine pain and strain, and a BM quality scale.

The Reduced Nitridogermanates(III) Ca [Ge N ] and Sr [Ge N ] with Ge-Ge Bonds.

The first nitridogermanates(III) Ca [Ge N ] and Sr [Ge N ] were synthesized from sodium flux and structurally characterized by powder and single crystal X-ray diffraction, respectively. They crystallize isostructurally to each other and homeotypic to Ca [Cr N ]H in space group R . They feature unprecedented, mutually isolated, ethane-like [Ge N ] anions in a staggered conformation.

Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function?

Angiosperm mitochondrial (mt) genes are generally slow-evolving, but multiple lineages have undergone dramatic accelerations in rates of nucleotide substitution and extreme changes in mt genome structure. While molecular evolution in these lineages has been investigated, very little is known about their mt function. Some studies have suggested altered respiration in individual taxa, although there are several reasons why mt variation might be neutral in others.

A CREB3-regulated ER-Golgi trafficking signature promotes metastatic progression in breast cancer.

In order to better understand the process of breast cancer metastasis, we have generated a mammary epithelial progression series of increasingly aggressive cell lines that metastasize to lung. Here we demonstrate that upregulation of an endoplasmic reticulum (ER) to Golgi trafficking gene signature in metastatic cells enhances transport kinetics, which promotes malignant progression. We observe increased ER-Golgi trafficking, an altered secretome and sensitivity to the retrograde transport inhibitor brefeldin A (BFA) in cells that metastasize to lung.