Publications by authors named "L A Linares"
: Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Nirsevimab has demonstrated to be a promising tool for preventing severe RSV disease. Although clinical trials have demonstrated the efficacy of Nirsevimab in preventing severe RSV disease, evidence regarding its performance in real-world clinical settings is still limited due to its recent introduction.
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- Dedifferentiated and Well-differentiated liposarcoma tumors show an increase in the MDM2 oncogene, which drives tumor growth through unique metabolic functions.
- The study finds that liposarcoma cells rely on serine produced by distant muscle tissues for survival, although the source of serine is not fully understood.
- Treatment with an FDA-approved anti-interleukine-6 monoclonal antibody can hinder serine synthesis and lead to decreased tumor growth and increased cancer cell death, suggesting a potential therapy for liposarcoma patients.*
Dedifferentiated liposarcoma (DDLPS) is the most frequent high-grade soft tissue sarcoma subtype. It is characterized by a component of undifferentiated tumor cells coexisting with a component of well-differentiated adipocytic tumor cells. Both dedifferentiated (DD) and well-differentiated (WD) components exhibit MDM2 amplification, however their cellular origin remains elusive.
View Article and Find Full Text PDFAdenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA modification within the brain. Yet, most research has relied on postmortem samples, assuming it is an accurate representation of RNA biology in the living brain. We challenge this assumption by comparing A-to-I editing between postmortem and living prefrontal cortical tissues.
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