Does Topical Steroid Use Increase the Risk for Subsequent Tympanoplasty?

Objectives: Although the current data support the notion that combination therapy of topical steroids with antibiotics is a safe, and often superior, option for suppurative otitis media when compared to topical antibiotics alone, little is known about the impact of topical steroids on tympanic membrane (TM) healing and risk of residual perforation. This study aims to describe the long-term impact the addition of topical steroids to antibiotics has on TM healing, as measured by rates of subsequent tympanoplasty.

Methods: Electronic health records were queried using TriNetX Research Network to construct cohorts of adult patients with "infected" TM perforation (ICD-10 code H66) and "noninfected" TM perforation (ICD-10 code H72).

A Literature Review on Equine Bedding: Impacts on Horse and Human Welfare, Health, and the Environment.

Bedding is an important component of equine accommodation management. Choosing the right bedding is important for stable management and its selection may include considerations such as the sourcing of the material, the capital investment and ongoing costs, delivery, storage, installation, ongoing labour and maintenance, removal and disposal. Furthermore, it is crucial that the consequences for the health and welfare of horses and humans and the impact on the environment should also be considered.

A Neuroimmune-Oncology Microphysiological Analysis Platform (NEO-MAP) for Evaluating Astrocytic Scar Formation and Microgliosis in Glioblastoma Microenvironment.

Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, characterized by its heterogeneity in cellular components, including reactive astrocytes and microglia. Since neuroimmune responses like astrogliosis and microgliosis gain recognition as vital factors in brain tumor progression, there is a growing need for clinically relevant models that assess the interactions between astrocytes, microglia, and GBM. Here, a NEuroimmune-Oncology Microphysiological Analysis Platform (NEO-MAP) is presented as a "new map" to observe astrocytic scar formation and microgliosis in response to GBM.