Publications by authors named "L A Lange"
Recent advancements in Parkinson's disease (PD) drug development have been significantly driven by genetic research. Importantly, drugs supported by genetic evidence are more likely to be approved. While genome-wide association studies (GWAS) are a powerful tool to nominate genomic regions associated with certain traits or diseases, pinpointing the causal biologically relevant gene is often challenging.
View Article and Find Full Text PDFAims/hypothesis: This is the first study to examine the association between variants of the glucagon-like-peptide-1 receptor gene (GLP-1R) and metabolic characteristics among youth. We explored separate associations of three GLP-1R polymorphisms (rs10305420, rs6923761, and rs1042044) with BMI trajectories and markers of glucose-insulin homeostasis.
Methods: Mixed models examined associations between GLP-1R polymorphisms and trajectories of BMI.
The pulp of açaí palm fruits ( Mart.) is a valuable export commodity in Brazil. Its production generates 1.
View Article and Find Full Text PDFArticle Synopsis
- Frontal alpha asymmetry was thought to indicate levels of approach motivation, but recent studies found little connection between it and personality traits.
- A study using data from the CoScience project (n=740) measured frontal asymmetry during different tasks to see if it varied based on approach motivation.
- The results showed that frontal asymmetry wasn't significantly influenced by the tasks and did not correlate with self-reported personality traits, undermining its validity as a marker for approach motivation.
Article Synopsis
- The release of Genome Aggregation Database (gnomAD) v4 significantly increases sample size, impacting the interpretation of genetic variants, particularly in dystonia.
- A comparison of variants linked to common forms of isolated dystonia showed that most (77.7%) remained absent in the new version; however, some well-known pathogenic variants were newly recorded in v4.
- Despite finding more dystonia-related alleles in gnomAD v4, the authors stress that the presence of these variants in population data doesn't automatically mean they aren't pathogenic.