Publications by authors named "L A Kulakova"

Article Synopsis
  • Epivolve is a cutting-edge technology designed to create antibodies that specifically target certain sites on a pathogen by using modified peptides or proteins as immunogens.* -
  • The technology was tested on the SARS-CoV-2 Receptor Binding Domain, leading to the development of neutralizing antibodies against 13 specific sites that interact with the ACE2 receptor.* -
  • One targeted site (SL13) was selected for more in-depth study, showcasing the ability of Epivolve to generate effective antibodies against both the original virus strain and its Omicron variant.*
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Background: Canine babesiosis is a common disease in the northern part of the Republic of Kazakhstan, in particular in the Kostanay region. In recent years, a large number of cases of the disease with a variety of clinical symptoms have been registered.

Aim: The purpose of the study was to monitor the spread, characterization, and identify the species involved of species in ticks and blood of dogs in the Kostanai region.

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Giardiasis is a disease caused by the protist Giardia lamblia. As no human vaccines have been approved so far against it, and resistance to current drugs is spreading, new strategies for combating giardiasis need to be developed. The G.

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Giardiasis, caused by the intestinal parasite , is a severe diarrheal disease, endemic in poverty-stricken regions of the world, and also a common infection in developed countries. The available therapeutic options are associated with adverse effects, and resistance to the standard-of-care drugs is spreading. Fumagillin, an antimicrosporidiosis drug, is a therapeutic agent with potential for the treatment of giardiasis.

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The influence of alternating strains on the spectral characteristics of the radiation of quantum-dimensional heterolasers is studied experimentally and theoretically. A brief review of the previously obtained results of the study of the deformation effect on the frequency spectrum of radiation is presented. A detailed analysis of the results obtained recently in the study of the influence of ultrasonic strain on the polarization properties of laser structures of various compositions is carried out.

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