[Molecular Mechanisms of Interactions between Mitochondria and the Endoplasmic Reticulum: A New Look at How Important Cell Functions are Supported].

Interactions between the endoplasmic reticulum (ER) and mitochondria have received insufficient attention until recently. However, distorted contacts between the ER and mitochondria were identified as an important factor in the etiopathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. In view of these new data, the mechanisms of ER-mitochondrial interactions are necessary to study in detail in order to develop new diagnostic and therapeutic approaches to neurodegenerative diseases and to extend basic knowledge of the physiology of the eukaryotic cell.

Factors affecting the results of analgesic therapy. Results of the Russian multicentre study of NOTE (NSAID: Open-label Trial of Efficacy).

Aim: To identify factors affecting the effectiveness of NSAIDs in patients with OA and LBP.

Materials And Methods: An observational study was conducted to evaluate the effectiveness of a 2-week course of NSAIDs in OA and LBP in real clinical practice. The study group consisted of 3604 patients with OA and LBP (60.

Interleukin-6 in neurons of the pterygopalatine ganglion of the rat.

An indirect immunofluorescence method was used to study the pterygopalatine nerve ganglion in rats with the aim of determining the identification and locations within it of neurons expressing IL-6. A low density of IL-6-immunoreactive cells was seen in the cranial area of the ganglion; the medial surface and caudal area contained occasional cells demonstrating nuclear fluorescence; rarer groups of cells, organized into chains, were seen in the intermediate part of the ganglion on its lateral margin contacting the maxillary nerve.

Apoptosis in cells of rat sympathetic ganglia during early ontogeny: electron microscopic study.

Postnatal ontogeny of sympathetic ganglia includes both proliferative processes and programmed cell death. Electron microscopy helps to evaluate the intensity and the relationship between these processes.