Publications by authors named "L A Kaminsky"
Aims: To better characterize functional consequences of the presence of COPD on cardiorespiratory fitness in patients with HF.
Methods And Results: Patients with any clinical indication for cardiopulmonary exercise testing (CPET) were included in the international FRIEND registry. Diagnosis of COPD was confirmed by a ratio of forced expiratory volume in 1 s and forced vital capacity (FEV/FVC) < 0.
Background: Indexing peak oxygen uptake (VOpeak) to total body mass can underestimate cardiorespiratory fitness (CRF) in women, older adults, and individuals with obesity. The primary objective of this multicenter study was to derive and validate a body size-independent scaling metric for VOpeak. This metric was termed exercise body mass (EBM).
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- The study aimed to find the cardiorespiratory fitness (CRF) levels necessary for older adults (70-77 years) to reduce their risk of death, hypothesizing that higher peak oxygen uptake (VO) would be protective.
- The research included a cohort of 1,565 older adults in Norway, who underwent VO testing and were monitored for all-cause mortality over five years.
- Results indicated that lower VO levels (less than 26.5 mL/kg/min for men and 22.2 mL/kg/min for women) significantly increased the risk of death, emphasizing the need for maintaining or improving CRF in later life.
Article Synopsis
- A study analyzed CPET results from over 7,000 individuals with coronary artery disease (CAD) to explore sex differences in achieving key exercise thresholds (VO2max and VT1).
- It found that a significantly higher percentage of males (89.7%) achieved these thresholds compared to females (71.3%), indicating a notable disparity.
- Factors contributing to females’ lower achievement rates included being female, older age, specific testing methods, depressive symptoms, and having a secondary heart failure diagnosis, suggesting a need for tailored strategies in exercise testing for females.
Background: Defective intestinal epithelial tight junction (TJ), characterized by an increase in intestinal TJ permeability, has been shown to play a critical role in the pathogenesis of inflammatory bowel disease (IBD). Tumor necrosis factor-α (TNF-α) is a key pro-inflammatory cytokine involved in the immunopathology of IBD and has been shown to cause an increase in intestinal epithelial TJ permeability. Although TNF-α antibodies and other biologics have been advanced for use in IBD treatment, these therapies are associated with severe side effects and have limited efficacy, and there is an urgent need for therapies with benign profiles and high therapeutic efficacy.
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