Exploring Gluconamide-Modified Silica Nanoparticles of Different Sizes as Effective Carriers for Antimicrobial Photodynamic Therapy.

Antimicrobial resistance (AMR), a consequence of the ability of microorganisms, especially bacteria, to develop resistance against conventional antibiotics, hampering the treatment of common infections, is recognized as one of the most imperative health threats of this century. Antibacterial photodynamic therapy (aPDT) has emerged as a promising alternative strategy, utilizing photosensitizers activated by light to generate reactive oxygen species (ROS) that kill pathogens without inducing resistance. In this work, we synthesized silica nanoparticles (NPs) of different sizes (20 nm, 80 nm, and 250 nm) functionalized with the photosensitizer Rose Bengal (RB) and a gluconamide ligand, which targets Gram-negative bacteria, to assess their potential in aPDT.

Machine-Learning-Based Spectral Modeling: A Biomimetic Guide for Enhancing Esthetics.

Objective: To provide guidelines and means for optimal coverage and distribution of computer models with 1-10 clusters, designed based on an in vivo extensive dental colorimetric database and compare the findings with some reputable shade guides.

Materials And Methods: The Fuzzy C-Means (FCM) algorithm was used to optimize the tab position in the CIELAB color space, while MATLAB Fuzzy Logic was used to implement the codes. A minimization process was performed to fine-tune the cluster centers, minimizing Coverage Error (CE) and Maximum Error (ME).

Modified Landauer Principle According to Tsallis Entropy.

The Landauer principle establishes a lower bound in the amount of energy that should be dissipated in the erasure of one bit of information. The specific value of this dissipated energy is tightly related to the definition of entropy. In this article, we present a generalization of the Landauer principle based on the Tsallis entropy.

Bovine brucellosis in dual-purpose cattle herds and its potential economic impact in the Colombian Caribbean region.

Bovine brucellosis (BB) is a cosmopolitan zoonotic disease caused by certain bacteria of the genus Brucella. It has negative health implications for the cattle, economic implications for the owners and is present in numerous cattle and wildlife populations worldwide. To determine the seroprevalence of BB in dual-purpose herds and assess its impact in the southern part of the Department of Atlántico, northern Colombia.