EEG Authentication System Based on One- and Multi-Class Machine Learning Classifiers.

In the current Information Age, it is usual to access our personal and professional information, such as bank account data or private documents, in a telematic manner. To ensure the privacy of this information, user authentication systems should be accurately developed. In this work, we focus on biometric authentication, as it depends on the user's inherent characteristics and, therefore, offers personalized authentication systems.

Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against .

Gallinamide A, a metabolite of the marine cyanobacterium sp., selectively inhibits cathepsin L-like cysteine proteases. We evaluated the potency of gallinamide A and 23 synthetic analogues against intracellular amastigotes and the cysteine protease, cruzain.

In silico identification of noncompetitive inhibitors targeting an uncharacterized allosteric site of falcipain-2.

Falcipain-2 (FP-2) is a Plasmodium falciparum hemoglobinase widely targeted in the search for antimalarials. FP-2 can be allosterically modulated by various noncompetitive inhibitors that have been serendipitously identified. Moreover, the crystal structures of two inhibitors bound to an allosteric site, termed site 6, of the homolog enzyme human cathepsin K (hCatK) suggest that the equivalent region in FP-2 might play a similar role.

Real-Time Tool Detection for Workflow Identification in Open Cranial Vault Remodeling.

Deep learning is a recent technology that has shown excellent capabilities for recognition and identification tasks. This study applies these techniques in open cranial vault remodeling surgeries performed to correct craniosynostosis. The objective was to automatically recognize surgical tools in real-time and estimate the surgical phase based on those predictions.

Computational study on the allosteric mechanism of IF4E-1 by 4E-interacting protein-1: Unravelling the determinants of mGTP cap recognition.

During their life cycle, parasites display a fine-tuned regulation of the mRNA translation through the differential expression of isoforms of eukaryotic translation initiation factor 4E (LeishIF4Es). The interaction between allosteric modulators such as 4E-interacting proteins (4E-IPs) and LeishIF4E affects the affinity of this initiation factor for the mRNA cap. Here, several computational approaches were employed to elucidate the molecular bases of the previously-reported allosteric modulation in exerted by 4E-IP1 (Lm4E-IP1) on eukaryotic translation initiation factor 4E 1 (LmIF4E-1).