Publications by authors named "L A Hagberg"
Article Synopsis
- * Among the participants, asymptomatic CSF-E was found in only 2% of individuals and 1% of samples, indicating a low incidence.
- * While CSF-E was linked to signs of immune activation and potential blood-brain barrier issues, it did not correlate with indicators of neuronal damage.
Background: Alcoholism increases the risk of skin and skin structure infections (SSSIs). Furthermore, in complicated SSSIs (cSSSIs) alcoholism is associated with delayed treatment response and a higher risk of blood culture positivity, suggesting poor outcomes. In pneumonia and bacteremia alcoholism is linked with higher mortality, longer hospital treatment and more ICU treatment.
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- Researchers used the Olink Explore 1536 platform to analyze 1,463 unique proteins in cerebrospinal fluid (CSF) from 303 samples, including uninfected controls and various groups of individuals with HIV-1 infection.
- The study found significant correlations between CSF proteins and HIV-1 RNA levels, as well as nerve damage markers, highlighting distinct patterns of protein changes associated with different stages of HIV-1 progression.
- Antiretroviral therapy was shown to lessen protein imbalances in the CSF, although levels didn’t always return to those of uninfected controls; a comprehensive dataset is available online for further research on HIV-1's effects on the CNS.
Because senescence impairs the ability of older males to compete successfully for mates, male reproductive strategies are expected to change with age. The terminal investment hypothesis proposes that older males, who could die soon, should take greater risks to obtain mating opportunities. Another possibility is that older males avoid such risks, adopting alternative reproductive tactics, such as increased affiliation with females, increased reliance on coalitions or sexual coercion to continue to compete with younger animals.
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