Haplotype-based Analysis of 6q24-25 for Association with Rheumatoid Arthritis.

Background: Rheumatoid arthritis (RA) is a multisystem inflammatory disorder. Family history of RA is an important risk factor as it is strongly linked with the inherited HLA-DR4 (most specifically DR0401 and 0404). The aim of this study is to conduct the haplotype-based analysis of 6q24-25 and evaluate its association with RA.

Role of miRNA Let-7 in Plasma of Rheumatoid Arthritis.

: Micro ribonucleic acids (miRNAs) are noncoding RNAs, recently implicated as potential biomarkers or therapeutic targets for autoimmune diseases such as rheumatoid arthritis (RA). The aim of this study is to assess the role of miRNA Let-7 in the plasma of RA. : Trained medical staff already enrolled for the study collected blood samples from healthy controls ( = 42) and RA patients ( = 44).

Study of Association of Chromosomal Region 1Q21-23 with Rheumatoid Arthritis and Their Correlation with Severity of Disease.

Background: The understanding of the pathophysiology of rheumatoid arthritis (RA) has taken a major step forward with the research of new illness-related genes and further deciphering the involved molecular. Gene variants like human leukocyte antigen (HLA)-DRB1 and PTPN22 1858T act as individual risk factors for RA. It also serves as a risk factor for the rate of progression of joint destruction and clinical manifestations in autoimmune diseases like RA.

Study of Cardiovascular Involvement in Rheumatoid Arthritis and it's Correlation with Severity of Disease.

Unlabelled: Rheumatoid arthritis is a chronic systemic disease of unknown ethology characterised by persistent inflammatory synovitis usually affecting peripheral joints with symmetric distribution. Most common cause of death in RA is cardiovascular disease and pericarditis is the most common form of cardiac involvement. Valvular disorders, coronary vasculitis and ventricular diastolic dysfunction can be seen.