Publications by authors named "L A Fein"
Purpose: Alpelisib plus fulvestrant demonstrated a significant progression-free survival benefit versus fulvestrant in patients with PIK3CA-mutated HR+ /HER2- advanced breast cancer (ABC) (SOLAR-1). Hyperglycemia, an on-target adverse effect of PI3Kα inhibition, can lead to dose modifications, potentially impacting alpelisib efficacy. We report data from preclinical models and two clinical trials (SOLAR-1 and BYLieve) on Sodium glucose cotransporter 2 inhibitor (SGLT2i) use to improve PI3Kα inhibitor-associated hyperglycemia.
View Article and Find Full Text PDFBackground: POLARIS (phase 2 [ph2]; NCT03911869) evaluated encorafenib (BRAF inhibitor) in combination with binimetinib (MEK1/2 inhibitor) in BRAF/MEK inhibitor-naïve patients with V600-mutant melanoma with asymptomatic brain metastases.
Methods: The safety lead-in (SLI) assessed tolerability for high-dose encorafenib 300 mg twice daily (BID) plus binimetinib 45 mg BID. If the high dose was tolerable in ph2, patients would be randomized to receive high or standard dose (encorafenib 450 mg once daily [QD] plus binimetinib 45 mg BID).
Article Synopsis
- This study investigates the impact of HIV-related stigma on transgender women (TGW) living with HIV in Miami, FL, highlighting a gap in current understanding.
- In a small survey conducted during HIV clinical visits, findings revealed low levels of HIV-related stigma among the TGW participants, differing from earlier studies.
- The research suggests increased acceptance of TGW with HIV may be a reason for this low stigma and emphasizes the need for larger studies to better understand and reduce stigma.
Gender Identity Stigma in Transgender Women Is Higher After Gender-Affirming Vaginoplasty.
AIDS Res Hum Retroviruses
June 2024
Article Synopsis
- - The study explores how gender-affirming vaginoplasty impacts stigma and behaviors associated with HIV risk among transgender women (TW), highlighting the need for further research in this area.
- - It involved 30 TW without HIV, comparing those who had undergone vaginoplasty (TWWV) and those who had not (TWWOV), revealing higher levels of stigma and social oppression in TWWV, alongside greater body satisfaction.
- - Despite improvements in personal satisfaction for TWWV, risk behaviors for HIV, such as survival sex work and multiple sex partners, remained prevalent, indicating a need for targeted interventions to reduce HIV risks in this population.