Publications by authors named "L A Fearfield"
Br J Dermatol
October 2023
Article Synopsis
- * Common skin reactions include inflammatory conditions like eczema and psoriasis, as well as rashes and itching; most can be managed without halting ICI treatment.
- * The review emphasizes recognizing these skin reactions, identifying severe cases, and offering management strategies for both common and rare irAEs.
Br J Dermatol
December 2022
Article Synopsis
- Checkpoint inhibitors (CPI) have significantly improved survival rates for various cancers but can lead to rare autoimmune blistering disorders, such as bullous pemphigoid (BP).
- A study reviewed bullous skin-related immune adverse events associated with CPI therapy in over 7,300 patients, finding that BP occurred in 0.3% of cases, predominantly affecting older males with cutaneous melanoma.
- Most patients experienced symptoms within 12 months of treatment, and management often required multiple lines of therapy, with a considerable number of patients needing to discontinue or pause CPI treatments due to skin toxicity.
