Publications by authors named "L A Feagins"
Objectives: Fatigue is commonly reported in patients with Crohn's disease (CD) and ulcerative colitis (UC), including patients with inactive disease. We explored the impact of fatigue on healthcare utilization (HCU) and work productivity and activity impairment (WPAI).
Methods: Data collected between 2017 and 2022 were analyzed from the CorEvitas IBD Registry.
Background: Because biologic and small molecule therapy is expensive, payors have mandated pre-authorizations for these medications, often resulting in a lengthy approval process. The aims of this study are to assess the frequency of and risk factors for delays in starting advanced therapies assessing insurance, care team, and patient-related factors.
Methods: Retrospective, multi-center study of adult inflammatory bowel disease patients with prescriptions for an advanced therapy in two geographically distinct academic gastroenterology practices; one with and the other without a dedicated pharmacist.
Article Synopsis
- Current guidelines on octreotide therapy duration for esophageal variceal hemorrhage (EVH) are unclear, prompting a randomized clinical trial comparing 24-hour and 72-hour infusions of the drug.
- The study, which was terminated early due to recruitment issues during COVID-19, found no significant differences in complications or rebleeding rates between the two infusion durations.
- Results suggested that a 24-hour infusion may be just as effective as a 72-hour infusion, potentially leading to shorter hospital stays and reduced healthcare costs.
Article Synopsis
- - Cronkhite-Canada Syndrome (CCS) is a rare polyposis condition affecting 1 in a million, with unknown causes and treatments due to its scarcity and lack of research models.
- - Researchers created human intestinal organoids (HIOs) from two CCS patients, finding that these organoids are highly proliferative and produce more serotonin (5HT), which is linked to the growth of intestinal tissue.
- - The study highlights how organoid cultures can help understand CCS's disease mechanisms and could lead to personalized treatments, demonstrating the impact of intestinal hormones on epithelial cell growth.