Publications by authors named "L A Eriksson"
Objective: Composite primary outcomes (CPO) (incorporating both mortality and non-mortality outcomes) offer several advantages over mortality as an outcome for critical care research. Our objective was to explore and map the literature to report on CPO evaluated in critical care research.
Data Sources: PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Scopus, and Cochrane Library from January 2000 to January 2024.
The multifactorial nature of cancer requires treatment that involves simultaneous targeting of associated overexpressed proteins and cell signaling pathways, possibly leading to synergistic effects. Herein, we present a systematic study that involves the simultaneous inhibition of human topoisomerases (hTopos) and histone deacetylases (HDACs) by multitargeted quinoline-bridged hydroxamic acid derivatives. These compounds were rationally designed considering pharmacophoric features and catalytic sites of the cross-talk proteins, synthesized, and assessed for their anticancer potential.
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- The apoptosome plays a crucial role in regulating apoptosis through specific interactions between proteins with Caspase Activation and Recruitment Domain (CARD).
- This study conducted a detailed computational analysis to identify key residues involved in the interaction between the CARD domains of Apaf-1 and Caspase-9, highlighting their importance for apoptosome function.
- The findings also revealed that native interactions are more stable than those predicted between different complexes, emphasizing the specificity needed for effective protein interactions in apoptosis regulation.
Objective: To test the efficacy of a web-based psychoeducational intervention, Fex-Can Sex, in reducing sexual dysfunction in young adults with cancer.
Methods: This randomized controlled trial evaluated a 12-week web-based self-help intervention. Young adults aged 19-40 who reported sexual dysfunction 1.
Introduction: Sport and outdoor activities have benefits on people's health and well-being but may also increase the frequency of unsustainable behaviors. The present study explores drivers of travel mode choice and consumption of material (clothes and equipment) associated with physical activity to clarify the extent to which an active and sustainable lifestyle is compatible. The role of identity and varying levels of internalized motivation for pro-environmental behaviors (autonomous and controlled environmental motivation) and engagement in physical activity (autonomous and controlled activity motivation) was examined.
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