Putative diagnosis of neuromuscular and vascular hamartoma: 2 cases in dogs and review of the veterinary literature.

Neuromuscular and vascular hamartoma (NMVH) is an infrequent gastrointestinal lesion described in human and veterinary medical literature. The histologic features of this entity are haphazardly arranged fascicles of smooth muscle, nerve fibers, scattered ganglion cells, and hemangiomatous blood vessels. Here we describe 2 putative cases of NMVH in a 1.

Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists.

Background: Mas-related G protein-coupled receptor X2 (MRGPRX2) is a promiscuous receptor on mast cells that mediates IgE-independent degranulation and has been implicated in multiple mast cell-mediated disorders, including chronic urticaria, atopic dermatitis, and pain disorders. Although it is a promising therapeutic target, few potent, selective, small molecule antagonists have been identified, and functional effects of human MRGPRX2 inhibition have not been evaluated in vivo.

Objective: We sought to identify and characterize novel, potent, and selective orally active small molecule MRGPRX2 antagonists for potential treatment of mast cell-mediated disease.

Efficacy of Esketamine among patients with treatment resistant depression in a 'real world' health-care setting in Israel.

One in five people will likely suffer from major depressive disorder (MDD) during their life. Thirty percent of those with MDD will experience Treatment Resistant Depression (TRD), which is characterized by a failure to respond to two adequately administered trials of antidepressants. Esketamine is a rapidly acting intranasal antidepressant.

Advanced (bio)fouling resistant surface modification of PTFE hollow-fiber membranes for water treatment.

Membrane surface treatment to modify anti-(bio)fouling resistivity plays a key role in membrane technology. This paper reports on the successful use of air-stimulated surface polymerization of dopamine hydrochloride incorporated ZnO nanoparticles (ZnO NPs) for impeding the intrinsic hydrophobicity and low anti-(bio)fouling resistivity of polytetrafluoroethylene (PTFE) hollow-fiber membranes (HFMs). The study involved the use of pristine and polydopamine (Pdopa) coated PTFE HFMs, both with and without the presence of an air supply and added ZnO NPs.