[Effect of external ionizing radiation on morphofunctional indices of the hypothalamus, hypophysis and adrenal glands].

The laboratory rats exposed to one-time external ionizing radiation have been found to have phase changes of morphofunctional and secretory cells activity of hypothalamus, hypophysis, cortex and medullary of adrenal glands. The first phase called reactive (3-7 days) is characterized by enhancing energy-producing, protein-synthesizing and secretory functions of secretory sells of hypothalamus supraoptic nucleus, corticotrophic cells of adenohypophysis, adrenocorticytes of cortex and adrenocytes of medullary of adrenal glands. The second phase of dystrophic changes (7-14) is characterized by different degree of distrophic-destructive changes.

[Efficacy of D-penicillamine and methotrexate in the treatment of rheumatoid arthritis in relation to levels of circulating rheumatoid factors of different classes].

Aim: To optimize treatment for rheumatoid arthritis (RA) and to define indications for D-penicillamine and methotrexate therapies on an individual basis by taking into account the levels of rheumatoid factor (RF) isotopes circulating in blood.

Materials And Methods: A total of 105 patients (mean age 46.39 +/- 1.