Education at the frontier between tradition and innovation: challenges of an international initiative in breaking through.

In a rapidly evolving global landscape, education stands as a linchpin for navigating complex challenges and fostering sustainable development. This article delves into the transformative potential of education, with a particular focus on insights gleaned from the KIDS4ALLL project. Rooted in contrasting perspectives of education, the study emphasizes the need for a paradigm shift toward fostering critical thinking, creativity, and inclusivity.

Cancer vaccines: Target antigens, vaccine platforms and preclinical models.

This review provides a comprehensive overview of the evolving landscape of cancer vaccines, highlighting their potential to revolutionize tumor prevention. Building on the success of vaccines against virus-related cancers, such as HPV- and HBV-associated cervical and liver cancers, the current challenge is to extend these achievements to the prevention of non-viral tumors and the treatment of preneoplastic or early neoplastic lesions. This review analyzes the critical aspects of preventive anti-cancer vaccination, focusing on the choice of target antigens, the development of effective vaccine platforms and technologies, and the use of various model systems for preclinical testing, from laboratory rodents to companion animals.

Integrating single nuclei and bulk RNA sequencing in rice shoot apical meristems uncovers candidate early floral transition gene networks.

We describe transcriptional dynamics at the rice shoot apex by integrating time resolved single nuclei RNA-seq with bulk RNA-seq data. In rice, short days trigger floral transition and the transcriptional reprogramming of the shoot apex to become reproductive. We integrated time-resolved bulk RNA-seq with single nuclei RNA-seq analysis to gain a refined understanding of the transcriptional programs induced at the shoot apex during floral transition.