Publications by authors named "L A Chiodo"
Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a critical threshold. It maintains cell homeostasis by enhancing protein folding, initiating quality control, and activating degradation pathways when damage is irreversible.
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- Most patients engaged in treatment for opioid use disorder (OUD) initially, but retention dropped significantly over time, with only 17.1% remaining in treatment after 24 months.
- Data showed that patients with opioid-positive tests at the start had a lower chance of achieving continuous abstinence, while those who tested opioid-negative had higher success rates.
- Early achievement of abstinence was crucial; patients who maintained sobriety for the first 6 months were much more likely to stay in treatment for the following year or two, highlighting the need for interventions aimed at supporting early stability in high-risk individuals.
The nematode Caenorhabditis elegans is a widely used model organism for neuroscience. Although its nervous system has been fully reconstructed, the physiological bases of single-neuron functioning are still poorly explored. Recently, many efforts have been dedicated to measuring signals from C.
View Article and Find Full Text PDFAmphid wing "C" (AWC) neurons are among the most important and studied neurons of the nematode In this work, we unify the existing electrical and intracellular calcium dynamics descriptions to obtain a biophysically accurate model of olfactory transduction in AWC neurons. We study the membrane voltage and the intracellular calcium dynamics at different exposure times and odorant concentrations to grasp a complete picture of AWC functioning. Moreover, we investigate the complex cascade of biochemical processes that allow AWC activation upon odor removal.
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