[Genetic typing of Mycobacterium tuberculosis strains by spoligotyping and genome fingerprinting techniques].

A total of 122 M. tuberculosis clinical drug-resistant strains isolated in Central Russia were studied by spoligotyping and genome fingerprinting techniques. According to spoligotyping results 77% of M.

[Free-radical mechanism of antimicrobial action of xanthine oxidase and lactoperoxidase].

The interaction between milk xanthine oxidase (XO) and lactoperoxidase (LP) in model system and antimicrobial action of these enzymes on Escherichia coli 0-111 were studied. It was shown, that bacterial superoxide dismutase (SOD), which transforms O2-. (XO-reaction product) into H2O2 (substrate of LP), is necessary for binding of the reaction sequence: XO-->LP-->antimicrobial products.

[Increased sensitivity of the parapertussis diagnostic agent].

The adsorption activity of formolated sheep red blood cells can be increased by their combined treatment with low-frequency ultrasound, tannin and Tween-40. The diagnosticums thus obtained have proved to be highly sensitive and specific and can be recommended for the detection of antibodies to Bordetella parapertussis in the sera of sick children.

[Characteristics of the low molecular antigens of pertussis bacteria].

The authors elaborated a method of obtaining pertussis soluble antigenic complex by dialysis through the cellophane membrane against the physiological saline at a temperature of 4 degrees C. An antigen which was active in the passive hemagglutination and neutralization of antibodies tests was revealed in the dialyzate. The amount of this antigen in the dialyzate increased gradually up to the 7th day and then became stabilized.