Publications by authors named "L A Chambers"
The Role of the Microbiome in Cancer Therapies: Current Evidence and Future Directions.
Hematol Oncol Clin North Am
January 2025
The microbiome is essential for maintaining human health and is also a key factor in the development and progression of various diseases, including cancer. Growing evidence has highlighted the microbiome's significant impact on cancer development, progression, and treatment outcomes. As research continues to unfold, the microbiome and its modulation stand out as a promising frontier in cancer research and therapy.
View Article and Find Full Text PDFThis study introduces a biomimetic approach to 3D printing multilayered hierarchical porous membranes (MHMs) using Direct Ink Writing (DIW) technology. Fabricated through a fast layer-by-layer printing process with varying concentrations of pore-forming agents, the produced MHMs mimic the hierarchical pore structure and filtration capabilities of natural soil systems. As a result, the 3D-printed MHMs achieved an impressive oil rejection rate of 99.
View Article and Find Full Text PDFBackground: The etiology of nongonococcal urethritis (NGU) is incompletely understood. We sought to determine if genitourinary bacterial diversity or specific taxa were associated with incident NGU.
Methods: From August 2014-July 2018, men who have sex with women attending a sexual health clinic were clinically evaluated, including Mycoplasma genitalium (MG) and Chlamydia trachomatis (CT) testing, at enrollment and six monthly visits.
Article Synopsis
- Emergency department visits present a key opportunity for delivering prevention services to individuals at high risk of opioid overdose, particularly by assessing their "recovery capital."
- This study analyzed data from 543 patients enrolled in a randomized controlled trial in Rhode Island, focusing on the relationship between recovery capital (measured by the BARC-10) and subsequent treatment engagement and overdose risk.
- The results indicated that the majority of patients had low recovery capital (BARC-10 score <47), and there was no significant association found between recovery capital and either 30-day treatment engagement or the risk of non-fatal or fatal overdoses within 18 months.
Article Synopsis
- Bacteria have operons similar to eukaryotic ubiquitination pathways, which include proteins involved in adding and removing ubiquitin-like molecules.
- Recent studies indicate some of these pathways help bacteria defend against bacteriophages, although many functions remain unclear.
- This research reveals unique structural diversity in bacterial ubiquitin-like proteins and suggests they form filaments that help bacteria respond to stress through calcium ion interactions.