Publications by authors named "L A Bugnon"

Motivation: Coding and noncoding RNA molecules participate in many important biological processes. Noncoding RNAs fold into well-defined secondary structures to exert their functions. However, the computational prediction of the secondary structure from a raw RNA sequence is a long-standing unsolved problem, which after decades of almost unchanged performance has now re-emerged due to deep learning.

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In UniProtKB, up to date, there are more than 251 million proteins deposited. However, only 0.25% have been annotated with one of the more than 15000 possible Pfam family domains.

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The automatic annotation of the protein universe is still an unresolved challenge. Today, there are 229,149,489 entries in the UniProtKB database, but only 0.25% of them have been functionally annotated.

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Motivation: In contrast to messenger RNAs, the function of the wide range of existing long noncoding RNAs (lncRNAs) largely depends on their structure, which determines interactions with partner molecules. Thus, the determination or prediction of the secondary structure of lncRNAs is critical to uncover their function. Classical approaches for predicting RNA secondary structure have been based on dynamic programming and thermodynamic calculations.

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The leafcutter ants (LCA) are considered plague in a great part of the American continent, causing great damage in production fields. Knowing the locomotion and foraging rhythm in LCA on a continuous basis would imply a significant advance for ecological studies, fundamentally of animal behavior. However, studying the forage rhythm of LCA in the field involves a significant human effort.

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