Assessment of DNA damage in somatic and germ cells of animals living with increased radiation background and their offspring.

Purpose: The aim of this work is to assess DNA damage in the somatic and germ cells in root voles living for a long time under conditions of an increased radiation background and to examine the of manifestation of long-term consequences in their offspring.

Materials And Methods: Using the DNA comet assay (neutral version), we assessed the proportion of cells with DNA damage in the cells of the thyroid, bone marrow and testicular in root voles ( Pall.) that lived under conditions of increased radiation background (exposure dose rate - 0.

Transgenerational effects in offspring of chronically irradiated populations of Drosophila melanogaster after the Chernobyl accident.

The zone of the Chernobyl nuclear disaster represents the largest area of chronic low-intensity radioactive impact on the natural ecosystems. The effects of chronic low-dose irradiation for natural populations of organisms and their offspring are unknown. The natural populations of Drosophila melanogaster sampled in 2007 in Chernobyl sites with different levels of radiation contamination were investigated.

[Ecological and genetic monitoring of muridae from populations undergone to the chronic irradiation].

In work the data of long-term researches of consequences of chronic irradiation and radioactive pollution on a population of muridaea living in a zone of failure on the Chernobyl atomic power station and in territory of Northern radioecological station are resulted. It is shown, that chronic influence by investigated factors leads to authentically significant change of size of the genetic load determined on a level cytogenetic damages, intensity of reproduction, fertility.

[Biological effects of phytoecdysteroids and chronic low-dose irradiation].

The influence of serpistene in dose of 5 and 50 mg/kg on chronic low-dose gamma-irradiation (22.6 cGy) effects on cytogenetic (abnormal sperm cell, marrow bone micronucleus) and function and morphology (thyroid and adrenal glands) parameters of mice was estimated. The serpistene modifies effects of gamma-irradiation depends on the administration regime and a dose of the substance.

Biological consequences of increased natural radiation background for Microtus oeconomus Pall. populations.

The results of long-term investigations (1981-1999) on the state of Microtus oeconomus Pall. (tundra vole) population, living under the increased natural radiation background for a long time (for more than 100 generations), are presented. Population density dynamics, morphophysiological parameters, state of the lipid peroxidation regulatory system in different tissues and the cytogenetic effects in bone marrow cells of animals have been analyzed.