Publications by authors named "L A Baldwin"
Matrix metallopeptidase 9 (MMP9) is a secreted zinc-dependent peptidase known for extracellular remodeling. MMP9 is elevated in tissues from women experiencing preterm labor, and previous research has shown that the addition of combined matrix metallopeptidases 2 and 9 (MMP2/9) enhances uterine contractions. We hypothesized that adding MMP9 alone would enhance myometrial contractions and that specific MMP9 inhibition would suppress uterine contractions.
View Article and Find Full Text PDFThe present paper provides the first documentation and assessment of the capacity of chlorogenic acid to induce hormetic dose-response relationships. The findings suggest that chlorogenic acid may induce anabolic (i.e.
View Article and Find Full Text PDFWe report the preparation of poly(ionic) polymer-wrapped single-walled carbon nanotube dispersions for chemiresistive methane (CH) sensors with improved humidity tolerance. Single-walled CNTs (SWCNTs) were noncovalently functionalized by poly(4-vinylpyridine) (P4VP) with varied amounts of a poly(ethylene glycol) (PEG) moiety bearing a Br and terminal azide group (Br-R). The quaternization of P4VP with Br-R was performed using continuous flow chemistry and Bayesian optimization-guided reaction selection.
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- A toolkit approach for integrating behavioral health services into primary care has shown some improvements in integration but not in patient-reported outcomes.
- The evaluation of the toolkit's implementation revealed high acceptability among providers and staff, with 74% openness to its use and positive matches to practice needs.
- However, notable gaps in feasibility and fidelity were observed, indicating that while practices supported the toolkit's use, actual implementation challenges remain significant.
Rosmarinic acid is a polyphenol found in numerous fruits and vegetables, consumed in supplement form, and tested in numerous clinical trials for therapeutic applications due to its putative chemopreventive properties. Rosmarinic acid has been extensively studied at the cellular, whole animal, and molecular mechanism levels, presenting a complex array of multi-system biological effects. Rosmarinic acid-induced hormetic dose responses are widespread, occurring in numerous biological models and cell types for a broad range of endpoints.
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